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Johns Hopkins Center for TB Research Johns Hopkins School of Medicine

TARGET now has more than 4300 unique transposon mutants!!!
Click here to browse our mutant collection
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Search our Mutants

Latest Hits!!!
Rv1874 Rv0241c
Rv2565 Rv2417c
Rv0584 Rv2258c
Updated May 12, 2009
Details
DescriptionMETHOXY MYCOLIC ACID SYNTHASE 4 MMAA4 (METHYL MYCOLIC ACID SYNTHASE 4) (MMA4) (HYDROXY MYCOLIC ACID SYNTHASE)
Accession numberRv0642c
Gene namemmaA4
Gene length906
Protein length301
Coordinates736298..737203
Orientation-
Molecular mass34670.34
Isoelectric point5.44

Database Crossreferences
Deletion Mutant Phenotype
in-vivoguinea pig
 mouse
 rabbit

in-vitroHBMEC
 macrophage

Mutant Survival in DeADMAn (Lamichhane et al., 2005)*

Strain NamePhenotype (Mouse)
JHU0642c-764[no data]
JHU0642c-863[no data]
JHU0642c-764[no data]
JHU0642c-333Not-Attenuated
JHU0642c-583[no data]
JHU0642c-764[no data]
JHU0642c-764[no data]
 

CDC1551 Homolog
ORFMT0670
Essentiality Prediction
Sassetti et al, 2003*non-essential

JHU Transposon Mutant(s) Available
NameMT#Rv#POIGene LengthAvailable from BEI
JHU0642c-764MT0670Rv0642c764948no (will be available later)
JHU0642c-863MT0670Rv0642c863948no (will be available later)
JHU0642c-764MT0670Rv0642c764948no (will be available later)
JHU0642c-583MT0670Rv0642c583948yes
JHU0642c-764MT0670Rv0642c764948yes
JHU0642c-764MT0670Rv0642c764948yes
  
For a list of currently available mutants, please visit BEI's transposon mutant webpage.

If we have not disrupted your gene using random mutagenesis, we may be able to create a knockout mutant for you.  Please click here  to submit a request.

References
Lamichhane, G., M. Zignol, N. J. Blades, D. E. Geiman, A. Dougherty, J. Grosset, K. W. Broman, and W. R. Bishai. (2003) Proc. Natl. Acad. Sci. USA 100:7213-7218. [Abstract/Free Full Text]
Sassetti, C. M., Boyd, D. H. & Rubin, E. J. (2003) Proc. Natl. Acad. Sci. USA 100:12989-12994. [Abstract/Free Full Text]
Lamichhane G, Tyagi S, Bishai WR (2005) Infect Immun. Apr;73(4):2533-40.
[Abstract/Free Full Text]